Atopica works due to its anti-inflammatory and antipruritic effects in the treatment of allergic dermatitis. It specifically targets the immune cells involved in the allergic response including T-lymphocytes and other cells like Langerhans cells, eosinophils and mast cells. It blocks the release of inflammatory molecules such as cytokines and histamines, breaking the itch-scratch cycle.1 Cyclosporine concentrates in the skin.2
References: 1. Steffan J et al. Vet Dermatol (2006);17;3-16. 2. Steffan J et al. Vet Dermatol 2003; 14, 248).
Atopica is supplied as soft capsules containing 10 mg, 25 mg, 50 mg or 100 mg of cyclosporine A. Atopica for Cats is an oral liquid cyclosporine 100mg/ml. It is available in two bottle sizes – 17ml for start-up dosing or 5ml for maintenance dosing. Atopica for Cats dip tube dispensing system enables dose withdrawal without spills. It is supplied with a calibrated dosing syringe.
Atopica for Dogs should be given at least 1 hour before or 2 hours after feeding. For further information or to discuss alternative modes of administation, please contact your Elanco representative.Atopica for Cats can be given with food or directly into the mouth.
Atopica for Cats is a concentrated liquid solution which means only a small amount needs to be given with each dose.It can be administered in the food or directly into the mouth.In studies approximately one - third of cats took Atopica for Cats in their food and two - thirds were dosed directly into the mouth.1 For more information on administration, click here
Reference 1: Roberts ES et al.J Feline Med Surg(2016);1 - 9.
Initially Atopica should be given daily for at least the first 4 weeks of therapy. Following this induction treatment period, if a satisfactory clinical improvement is seen the dose of Atopica may be tapered by decreasing the frequency of dosing from daily to every other day, and then to once every 3 to 4 days until a minimum frequency is reached which will maintain the desired therapeutic effect. If no response is obtained within the first 8 weeks, the treatment should be stopped.
Initially Atopica should be given once daily until a good response is obtained. Then taper the dose frequency according to clinical response: moving to every other day,then twice weekly. The lowest effective frequency of dosing should be used to maintain the remission of clinical signs.
Cats that are prescribed Atopica for Cats should:
Pet owners should be advised to minimize potential exposure of seronegative cats to Toxoplasma. Explain that they should: avoid feeding their cat raw meat; discourage hunting (bells on collar); prevent scavenging behavior where possible; keep cats indoors (some specialists advise there may be a stress component to allergic skin disease which could be exacerbated). Treatment with Atopica for Cats has been shown not to increase Toxoplasma oocyst shedding, a potential source of zoonotic disease.
There is no need to monitor blood levels of cyclosporine during administration of Atopica as no correlation has been shown between blood levels and efficacy or safety.
There are no contraindications to vaccinate a dog while on Atopica. Killed vaccines are recommended for dogs receiving Atopica, as the impact of cyclosporine on the immune response to modified live vaccines is unknown. For further discussion, please contact your Elanco representative
Occasionally cyclosporine may cause weight loss in cats; this may be due to anorexia or nausea. Progressive and persistent weight loss should be investigated and may require cessation of treatment.